Journal article
Response to physical rehabilitation and recovery trajectories following critical illness: Individual participant data meta-analysis protocol
JRA Jones, S Berney, MJ Berry, DC Files, DM Griffith, LA McDonald, PE Morris, M Moss, A Nordon-Craft, T Walsh, I Gordon, A Karahalios, Z Puthucheary, L Denehy
BMJ Open | BMJ PUBLISHING GROUP | Published : 2020
Abstract
Introduction The number of inconclusive physical rehabilitation randomised controlled trials for patients with critical illness is increasing. Evidence suggests critical illness patient subgroups may exist that benefit from targeted physical rehabilitation interventions that could improve their recovery trajectory. We aim to identify critical illness patient subgroups that respond to physical rehabilitation and map recovery trajectories according to physical function and quality of life outcomes. Additionally, the utilisation of healthcare resources will be examined for subgroups identified. Methods and analysis This is an individual participant data meta-analysis protocol. A systematic lite..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work is supported by an Austin Medical Research Foundation Project Grant. JRAJ received funding from Australian Government Research Training Program Scholarship to support her PhD studies. LD, SB and IG received funding from National Health and Medical Research Council (grant no 454717), Physiotherapy Research Foundation, Austin Medical Research Foundation and Australian and New Zealand Intensive Care Society related to this work. MM and AN-C received funding from National Institute of Nursing Research (NINR, grant no R01 NR011051) and National Heart, Lung, and Blood Institute (NHLBI, grant no K24 HL089223) from National Institutes of Health (NIH) related to this work. PEM, MJB and DCF received funding from NIH/NINR/NHLBI (grant no 1R01NR011186) related to this work. MJB received grant funding from Isagenix LLC outside the submitted work. DCF has received honoraria for consultancy from Cytovale. TW and DMG received funding from the Chief Scientist Office, Scotland (grant no CZH/4/531) related to this work. ZP has received honoraria for consultancy from Fresenius Kabi, Orion Pharmaceuticals, Lyric Pharmaceuticals, Faraday Pharmaceuticals and Nestle. The funders did not influence the study design or writing of this manuscript.